Pub. Date : 2016 Feb 10
PMID : 26861753
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin. | Daunorubicin | solute carrier family 22 member 1 | Homo sapiens |
| 2 | Using the high-grade serous ovarian cancer cell line TOV2223G, we show that OCT1 mediated the high affinity (Km ~ 5 muM) uptake of daunorubicin into the cells, and that micromolar amounts of choline completely abolished the drug entry. | Daunorubicin | solute carrier family 22 member 1 | Homo sapiens |
| 3 | OCT1 downregulation by shRNA impaired daunorubicin uptake into the TOV2223G cells, and these cells were significantly more resistant to the drug in comparison to the control shRNA. | Daunorubicin | solute carrier family 22 member 1 | Homo sapiens |