Pub. Date : 2016 May
PMID : 26861188
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Naringenin suppressed UVB-induced MMP-1 expression and AP-1 activity, and strongly suppressed UVB-induced phosphorylation of Fos-related antigen (FRA)-1 at Ser265. | naringenin | FOS like 1, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Importantly, UVB irradiation-induced FRA1 protein stability was reduced by treatment with naringenin, as well as with a mitogen-activated protein kinase (MEK) inhibitor. | naringenin | FOS like 1, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Naringenin exerts potent anti-photoaging effects by suppressing ERK2 activity and decreasing FRA1 stability, followed by down-regulation of AP-1 transactivation and MMP-1 expression. | naringenin | FOS like 1, AP-1 transcription factor subunit | Homo sapiens |