Title : Mice with Genetic Deletion of Group VIA Phospholipase A2β Exhibit Impaired Macrophage Function and Increased Parasite Load in Trypanosoma cruzi-Induced Myocarditis.

Pub. Date : 2016 Apr

PMID : 26857573






1 Functional Relationships(s)
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1 We have shown that PAF production is dependent upon calcium-independent group VIA phospholipase A2beta (iPLA2beta) following infection of human coronary artery endothelial cells (HCAECs) with T. cruzi, suggesting that the absence of iPLA2beta may decrease the recruitment of inflammatory cells to the heart to manage parasite accumulation. Calcium phospholipase A2 group VI Homo sapiens