Pub. Date : 2016 Feb 9
PMID : 26857144
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells. | Lithium | transforming growth factor beta induced | Homo sapiens |
| 2 | Lithium reduces the expression of transforming growth factor-beta-induced protein (TGFBIp) in colon cancer cells by inhibiting Smad3 phosphorylation via GSK3beta inactivation. | Lithium | transforming growth factor beta induced | Homo sapiens |
| 3 | Moreover, lithium inhibits lymphatic endothelial cell migration, which is increased upon TGFBIp expression in tumor cells. | Lithium | transforming growth factor beta induced | Homo sapiens |
| 4 | In tumor xenografts model, lithium was found to prevent metastasis to the lungs, liver, and lymph nodes by inhibiting TGFBIp-induced tumor lymphangiogenesis. | Lithium | transforming growth factor beta induced | Homo sapiens |
| 5 | Collectively, our findings demonstrate a novel role of lithium in the inhibition of colon cancer metastasis by blocking TGFBIp expression, and thereby TGFBIp-induced lymphangiogenesis, in primary tumors. | Lithium | transforming growth factor beta induced | Homo sapiens |
| 6 | Collectively, our findings demonstrate a novel role of lithium in the inhibition of colon cancer metastasis by blocking TGFBIp expression, and thereby TGFBIp-induced lymphangiogenesis, in primary tumors. | Lithium | transforming growth factor beta induced | Homo sapiens |