Title : The importance of the gastrorenal axis in the control of body sodium homeostasis.

Pub. Date : 2016 Apr

PMID : 26854262






7 Functional Relationships(s)
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1 This review describes the role of gastrin in the cross-talk between the stomach and the kidney following the ingestion of sodium. Sodium gastrin Homo sapiens
2 It is proposed that gastrin produced by G-cells via its receptor, cholecystokinin B receptor, interacts with renal D1 -like dopamine receptors to increase renal sodium excretion. Sodium gastrin Homo sapiens
3 The natriuresis following the ingestion of a certain amount of sodium may be due to an enterokine, gastrin, secreted by G-cells in the stomach and duodenum and released into the circulation. Sodium gastrin Homo sapiens
4 Gastrin, via its receptor, the cholecystokinin type B receptor (CCKBR), is natriuretic in mammals, including humans, by inhibition of renal sodium transport. Sodium gastrin Homo sapiens
5 Selective silencing of Gast in the stomach and duodenum impairs the ability to excrete an oral sodium load and also increases blood pressure. Sodium gastrin Homo sapiens
6 Thus, the gastrorenal axis, mediated by gastrin, can complement pronatriuretic hormones, such as dopamine, to increase sodium excretion after an oral sodium load. Sodium gastrin Homo sapiens
7 Thus, the gastrorenal axis, mediated by gastrin, can complement pronatriuretic hormones, such as dopamine, to increase sodium excretion after an oral sodium load. Sodium gastrin Homo sapiens