Pub. Date : 2016 Apr
PMID : 26853630
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The impact of glyLDL on the expression and activity of eNOS in vascular endothelial cells (EC) remains unknown. | glyldl | nitric oxide synthase 3 | Homo sapiens |
| 2 | The present study investigated the effect of glyLDL on the levels of protein, mRNA and activity of eNOS in cultured human umbilical vein EC. | glyldl | nitric oxide synthase 3 | Homo sapiens |
| 3 | The results demonstrated that incubation of EC with physiological concentrations of glyLDL significantly reduced the abundances of eNOS protein in EC with the maximal inhibition at 100mug/ml for 24h. | glyldl | nitric oxide synthase 3 | Homo sapiens |
| 4 | Blocking antibody against the receptor for advanced glycation end products (RAGE) prevented glyLDL-induced downregulation of eNOS in EC. | glyldl | nitric oxide synthase 3 | Homo sapiens |
| 5 | Farnesyl-transferase inhibitor-276, an H-Ras antagonist, normalized glyLDL-induced downregulation of eNOS and prevented glyLDL-induced upregulation of H-Ras in EC membrane. | glyldl | nitric oxide synthase 3 | Homo sapiens |
| 6 | Treatment with 4-phenylbutyric acid, an endoplasmic reticulum (ER) stress antagonist, prevented glyLDL-induced eNOS downregulation in EC. | glyldl | nitric oxide synthase 3 | Homo sapiens |
| 7 | ER stress induced by glyLDL is possibly involved in eNOS downregulation. | glyldl | nitric oxide synthase 3 | Homo sapiens |