Pub. Date : 2016 Apr 15
PMID : 26851491
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells. | Dasatinib | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 2 | We demonstrate that Dasatinib can actually interfere with SAMHD1 phosphorylation in human peripheral blood lymphocytes, preserving its antiviral activity against HIV-1. | Dasatinib | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 3 | Dasatinib prevented SAMHD1 phosphorylation in vitro and ex vivo, impairing HIV-1 reverse transcription and proviral integration. | Dasatinib | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 4 | This was the major mechanism of action because the presence of Vpx, which degrades SAMHD1, in HIV-1 virions impeded the inhibitory effect of Dasatinib on HIV-1 replication. | Dasatinib | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 5 | Finally, PBMCs from patients on chronic treatment with Dasatinib showed a lower level of SAMHD1 phosphorylation in response to activating stimuli and low susceptibility to HIV-1 infection ex vivo. | Dasatinib | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 6 | Consequently, Dasatinib is a compound currently used in clinic that preserves the antiviral function of SAMHD1. | Dasatinib | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |