PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26851491-0	2016	Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.	Dasatinib	0-9	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	65-71	
26851491-4	2016	We demonstrate that Dasatinib can actually interfere with SAMHD1 phosphorylation in human peripheral blood lymphocytes, preserving its antiviral activity against HIV-1.	Dasatinib	20-29	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	58-64	
26851491-5	2016	Dasatinib prevented SAMHD1 phosphorylation in vitro and ex vivo, impairing HIV-1 reverse transcription and proviral integration.	Dasatinib	0-9	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	20-26	
26851491-6	2016	This was the major mechanism of action because the presence of Vpx, which degrades SAMHD1, in HIV-1 virions impeded the inhibitory effect of Dasatinib on HIV-1 replication.	Dasatinib	141-150	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	83-89	
26851491-8	2016	Finally, PBMCs from patients on chronic treatment with Dasatinib showed a lower level of SAMHD1 phosphorylation in response to activating stimuli and low susceptibility to HIV-1 infection ex vivo.	Dasatinib	55-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	89-95	
26851491-9	2016	Consequently, Dasatinib is a compound currently used in clinic that preserves the antiviral function of SAMHD1.	Dasatinib	14-23	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	104-110