Title : Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo.

Pub. Date : 2016 Sep

PMID : 26850478






2 Functional Relationships(s)
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1 Our lab previously established the mammalian norepinephrine transporter (NET) inhibitor nisoxetine to be a potent antagonist of DA uptake conferred by DAT-1 following heterologous expression. nisoxetine solute carrier family 6 member 3 Homo sapiens
2 Here we demonstrate the ability of low (muM) concentrations of nisoxetine to trigger Swip within minutes of incubation, with paralysis dependent on DA release and signaling, and non-additive with Swip triggered by dat-1 deletion. nisoxetine solute carrier family 6 member 3 Homo sapiens