Title : Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression.

Pub. Date : 2016 Mar 8

PMID : 26848979






3 Functional Relationships(s)
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Protein Name
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1 EZH2 mRNA was significantly higher in CCSK compared to Wilms tumor and normal kidney, and the EZH2 protein was strongly expressed in more than 90 % of CCSK tumor cells in 9/9 tumors analyzed. ccsk enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
2 EZH2 mRNA was significantly higher in CCSK compared to Wilms tumor and normal kidney, and the EZH2 protein was strongly expressed in more than 90 % of CCSK tumor cells in 9/9 tumors analyzed. ccsk enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
3 This was in striking contrast to the lack of EZH2 protein expression in Wilms tumor stromal elements, indicating that EZH2 could be explored further as a diagnostic marker and a potential drug target for CCSK. ccsk enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens