Pub. Date : 2016 Feb 5
PMID : 26846307
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cisplatin resistance in gastric cancer cells is associated with HER2 upregulation-induced epithelial-mesenchymal transition. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | Herein, we found that HER2 upregulation was associated with cisplatin resistance. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | We observed that cisplatin-resistant gastric cancer cells underwent a morphological change similar to epithelial-mesenchymal transition (EMT) which is mediated by HER2 overexpression. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | More importantly, the IC50 and Resistance Index of resistant gastric cancer cells to cisplatin were also decreased by any of these treatments.We demonstrated that expression and amplification of HER2 positively correlated with expression of EMT-related transcription factor Snail in gastric cancer tissues. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | In conclusion, this study provides some clues of the association of cisplatin resistance with HER2 upregulation-induced EMT in gastric cancer cells. | Cisplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |