Title : PPARĪ±-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice.

Pub. Date : 2016 Dec

PMID : 26838045






1 Functional Relationships(s)
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1 The 2,4-D decreased cholesterol levels in Leydig cells of wild-type mice through down-regulating the expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase 1 and reductase, involved in de novo cholesterogenesis. Cholesterol 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 Mus musculus