Title : The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling.

Pub. Date : 2016 Jan 28

PMID : 26821066






5 Functional Relationships(s)
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1 CJ also provoked a slight activation of NF-kappaB, and consistent with this notion a combined treatment of CJ and the NF-kappaB inhibitor parthenolide (Pt) led to a remarkable synergistic cell death in T-ALL cells. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
2 CJ also provoked a slight activation of NF-kappaB, and consistent with this notion a combined treatment of CJ and the NF-kappaB inhibitor parthenolide (Pt) led to a remarkable synergistic cell death in T-ALL cells. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
3 CJ also provoked a slight activation of NF-kappaB, and consistent with this notion a combined treatment of CJ and the NF-kappaB inhibitor parthenolide (Pt) led to a remarkable synergistic cell death in T-ALL cells. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
4 CJ also provoked a slight activation of NF-kappaB, and consistent with this notion a combined treatment of CJ and the NF-kappaB inhibitor parthenolide (Pt) led to a remarkable synergistic cell death in T-ALL cells. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
5 Altogether, our data support the concept that inhibition of the SERCA pump may be a novel strategy for the treatment of T-ALL with HD-domain-mutant Notch1 receptors and that additional treatment with the NF-kappaB inhibitor parthenolide may have further therapeutic benefits. parthenolide nuclear factor kappa B subunit 1 Homo sapiens