Pub. Date : 2016 Feb
PMID : 26817709
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-beta1/Smad and GRAP pathways. | ruboxistaurin | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | OBJECTIVE: To investigate whether ruboxistaurin (a selective PKC-beta inhibitor) mediates renoprotective effect via interference with TGF-beta1/Smad-GRAP cross-signalling. | ruboxistaurin | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | A significant up-regulation of TGF-beta1, Smad2 and Smad3 mRNA expression was observed in diabetic rats, which was alleviated by administration of ruboxistaurin. | ruboxistaurin | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | Furthermore, immunoblotting showed a significant improvement in protein levels of TGF-beta1 (P < 0.01), Smad2/3 (P < 0.01) and p-Smad3 (P < 0.001) in diabetic rats treated with ruboxistaurin compared to untreated. | ruboxistaurin | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | CONCLUSION: These data suggest that the renoprotective effect of ruboxistaurin is possibly due to down-regulation of TGF-beta1/Smad pathway and normalization of GRAP protein expression. | ruboxistaurin | transforming growth factor, beta 1 | Rattus norvegicus |