Title : Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress.

Pub. Date : 2016 Mar

PMID : 26806299






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress. Berberine Janus kinase 2 Rattus norvegicus
2 Pretreatment with BBR also activated the JAK2/STAT3 signaling pathway in heart tissues, and co-treatment with AG490, a specific JAK2/STAT3 inhibitor, blocked not only the protective effects of BBR, but also the inhibition of BBR on MI/R-induced ER stress. Berberine Janus kinase 2 Rattus norvegicus
3 Pretreatment with BBR also activated the JAK2/STAT3 signaling pathway in heart tissues, and co-treatment with AG490, a specific JAK2/STAT3 inhibitor, blocked not only the protective effects of BBR, but also the inhibition of BBR on MI/R-induced ER stress. Berberine Janus kinase 2 Rattus norvegicus
4 In H9C2 cells, treatment with BBR (50 mumol/L) markedly reduced SIR-induced cell apoptosis, oxidative stress and ER stress, which were abolished by transfection with JAK2 siRNA. Berberine Janus kinase 2 Rattus norvegicus