Title : Inhibitory effects of nicotine derived from cigarette smoke on thymic stromal lymphopoietin production in epidermal keratinocytes.

Pub. Date : 2016 Apr

PMID : 26786889






3 Functional Relationships(s)
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1 Nicotine inhibition of TSLP production was abolished by pretreatments with alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) antagonists, AMP-activated protein kinase (AMPK) inhibitor, and phosphoinositide 3-kinase (PI3K) inhibitors. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Nicotine inhibition of TSLP production was abolished by pretreatments with alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) antagonists, AMP-activated protein kinase (AMPK) inhibitor, and phosphoinositide 3-kinase (PI3K) inhibitors. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 These results suggest that nicotine inhibits the expression of TSLP by suppressing the activation of NF-kappaB through the alpha7 nAChR-PI3K-AMPK signaling pathway. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus