Title : Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection.

Pub. Date : 2016

PMID : 26784987






1 Functional Relationships(s)
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1 In addition, one of the 9 active compounds, adenosine 5"-monophosphate (A5MP), and also its mimic 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) 5" phosphate (ZMP) inhibited RAD52 activity in vivo and exerted synthetic lethality against BRCA1 and BRCA2-mutated carcinomas. Adenosine Monophosphate BRCA1 DNA repair associated Homo sapiens