Title : The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.

Pub. Date : 2016 Mar

PMID : 26780438






1 Functional Relationships(s)
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1 Leptin increased protein levels of collagen I, TGF-beta and CTGF, Akt phosphorylation and O2(-) production in both cardiac myofibroblasts and vascular smooth muscle cells in culture, while LOX inhibition ameliorated these alterations. Superoxides leptin Rattus norvegicus