Protein Name leptin
Organism Rattus norvegicus
Gene ID 25608
Gene Symbol


UniProt P50596 (LEP_RAT)
Relationships Total Number of functionally related compound(s) : 693
Total Number of Articles : 1106


Gene Summary

Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; fatty liver disease (multiple); lipid metabolism disorder (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, Apr 2022]

  • leptin
  • obesity factor
  • OB
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