Title : How the imidazole ring modulates amyloid formation of islet amyloid polypeptide: A chemical modification study.

Pub. Date : 2016 Apr

PMID : 26777153






1 Functional Relationships(s)
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1 RESULTS: After an ethyl-acetate group was introduced to the His(18) of hIAPP by diethylpyrocarbonate (DEPC) modification, the pH dependent hIAPP fibrillation went to the opposite order and the number of intra-molecular hydrogen bonds decreased, while the possibility of His(18) participating in the formation of alpha-helical structures increased. ethyl acetate islet amyloid polypeptide Homo sapiens