Title : A 6-Base Pair in Frame Germline Deletion in Exon 7 Of RET Leads to Increased RET Phosphorylation, ERK Activation, and MEN2A.

Pub. Date : 2016 Mar

PMID : 26765577






2 Functional Relationships(s)
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1 In vitro expression showed that phosphorylation of the crucial tyrosine 905 was much stronger in the p.505_506del RET mutant compared with WT RET, indicating ligand-independent autophosphorylation. Tyrosine ret proto-oncogene Homo sapiens
2 In vitro expression showed that phosphorylation of the crucial tyrosine 905 was much stronger in the p.505_506del RET mutant compared with WT RET, indicating ligand-independent autophosphorylation. Tyrosine ret proto-oncogene Homo sapiens