Title : Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors.

Pub. Date : 2016 Mar 16

PMID : 26764897






1 Functional Relationships(s)
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1 Using a combination of conventional mutagenesis, unnatural amino acid incorporation, immunohistochemistry and MD simulations, we demonstrate the crucial contributions of these two Trp residues to receptor expression and function in two prototypical Cys-loop receptors, the anion-selective GlyR alpha1 and the cation-selective nAChR alpha7. Cysteine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens