Title : EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape.

Pub. Date : 2016 Mar 1

PMID : 26759242






1 Functional Relationships(s)
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1 Furthermore, we showed that one of these intermediates, fructose 1,6 bisphosphate (F1,6BP), directly binds to and enhances the activity of the EGFR, thereby increasing lactate excretion, which leads to inhibition of local cytotoxic T-cell activity. fructose-1,6-diphosphate epidermal growth factor receptor Homo sapiens