Protein Name mitogen activated protein kinase kinase 1
Organism Rattus norvegicus
Gene ID 170851
Gene Symbol

Map2k1

UniProt Q01986 (MP2K1_RAT)
Relationships Total Number of functionally related compound(s) : 269
Total Number of Articles : 460
Description

mitogen activated protein kinase kinase 1

Gene Summary

Enables ATP binding activity; MAP kinase kinase activity; and enzyme binding activity. Involved in several processes, including positive regulation of metabolic process; regulation of intracellular signal transduction; and regulation of muscle contraction. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • dual specificity mitogen-activated protein kinase kinase 1
  • ERK activator kinase 1
  • MAP kinase kinase 1
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Properties