Pub. Date : 2016 Jan
PMID : 26749359
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cardiac function in BRCA1/2 mutation carriers with history of breast cancer treated with anthracyclines. | Anthracyclines | BRCA1 DNA repair associated | Homo sapiens |
| 2 | Women with BRCA1/2 mutations who develop breast cancer (BC) may receive anthracyclines but their risk of cardiac dysfunction has not been investigated. | Anthracyclines | BRCA1 DNA repair associated | Homo sapiens |
| 3 | Our study tested the hypothesis that women with history of BRCA1/2 mutation-associated BC treated with anthracyclines have impaired parameters of cardiac function compared to similarly treated women with history of sporadic BC. | Anthracyclines | BRCA1 DNA repair associated | Homo sapiens |
| 4 | Mean age was 50 +- 9 years in both groups (P = 0.99) but BRCA1/2 mutation carriers had longer anthracycline treatment-to-enrollment time (7.5 +- 5.3 vs. 4.2 +- 3.3 years, P = 0.001). | Anthracyclines | BRCA1 DNA repair associated | Homo sapiens |
| 5 | In contrast to laboratory animal data, our findings indicate lack of elevated cardiac risk with the use of standard-doses of adjuvant anthracyclines in treatment of BRCA1/2 mutation carriers with early stage BC. | Anthracyclines | BRCA1 DNA repair associated | Homo sapiens |