PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26749359-0 2016 Cardiac function in BRCA1/2 mutation carriers with history of breast cancer treated with anthracyclines. Anthracyclines 89-103 BRCA1 DNA repair associated Homo sapiens 20-25 26749359-2 2016 Women with BRCA1/2 mutations who develop breast cancer (BC) may receive anthracyclines but their risk of cardiac dysfunction has not been investigated. Anthracyclines 72-86 BRCA1 DNA repair associated Homo sapiens 11-18 26749359-3 2016 Our study tested the hypothesis that women with history of BRCA1/2 mutation-associated BC treated with anthracyclines have impaired parameters of cardiac function compared to similarly treated women with history of sporadic BC. Anthracyclines 103-117 BRCA1 DNA repair associated Homo sapiens 59-66 26749359-7 2016 Mean age was 50 +- 9 years in both groups (P = 0.99) but BRCA1/2 mutation carriers had longer anthracycline treatment-to-enrollment time (7.5 +- 5.3 vs. 4.2 +- 3.3 years, P = 0.001). Anthracyclines 94-107 BRCA1 DNA repair associated Homo sapiens 57-62 26749359-11 2016 In contrast to laboratory animal data, our findings indicate lack of elevated cardiac risk with the use of standard-doses of adjuvant anthracyclines in treatment of BRCA1/2 mutation carriers with early stage BC. Anthracyclines 134-148 BRCA1 DNA repair associated Homo sapiens 165-172