Pub. Date : 2016 Feb 15
PMID : 26743084
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Utilizing primary cells and cell lines (including those with no discernible expression of ferroportin on their surface), we demonstrate that upon Fe loading, the multifunctional enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is recruited to the cell surface, "treadmills" apotransferrin in and out of the cell. | Iron | glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens |
| 2 | Utilizing primary cells and cell lines (including those with no discernible expression of ferroportin on their surface), we demonstrate that upon Fe loading, the multifunctional enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is recruited to the cell surface, "treadmills" apotransferrin in and out of the cell. | Iron | glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens |
| 3 | Kinetic analysis utilizing labeled ligand, GAPDH-knockdown cells, (55)Fe-labeled cells and pharmacological inhibitors of endocytosis confirmed GAPDH-dependent apotransferrin internalization as a prerequisite for cellular Fe export. | Iron | glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens |