Pub. Date : 2016 Feb 2
PMID : 26742006
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Androgen receptor expression predicts beneficial tamoxifen response in oestrogen receptor-alpha-negative breast cancer. | Tamoxifen | androgen receptor | Homo sapiens |
| 2 | In addition, the relevance of AR in determining tamoxifen treatment efficiency requires evaluation. | Tamoxifen | androgen receptor | Homo sapiens |
| 3 | PURPOSE: To investigate the tamoxifen predictive relevance of the AR protein expression in breast cancer. | Tamoxifen | androgen receptor | Homo sapiens |
| 4 | RESULTS: In patients with oestrogen receptor (ER)-negative tumours, expression of AR predicted decreased recurrence rate with tamoxifen (hazard ratio (HR)=0.34; 95% confidence interval (CI)=0.14-0.81; P=0.015), whereas the opposite was seen in the AR- group (HR=2.92; 95% CI=1.16-7.31; P=0.022). | Tamoxifen | androgen receptor | Homo sapiens |
| 5 | Patients with triple-negative and AR+ tumours benefitted from tamoxifen treatment (HR=0.12; 95% CI=0.014-0.95 P=0.044), whereas patients with AR- tumours had worse outcome when treated with tamoxifen (HR=3.98; 95% CI=1.32-12.03; P=0.014). | Tamoxifen | androgen receptor | Homo sapiens |
| 6 | CONCLUSIONS: AR can predict tamoxifen treatment benefit in patients with ER- tumours and triple-negative breast cancer. | Tamoxifen | androgen receptor | Homo sapiens |