PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26742006-0 2016 Androgen receptor expression predicts beneficial tamoxifen response in oestrogen receptor-alpha-negative breast cancer. Tamoxifen 49-58 androgen receptor Homo sapiens 0-17 26742006-2 2016 In addition, the relevance of AR in determining tamoxifen treatment efficiency requires evaluation. Tamoxifen 48-57 androgen receptor Homo sapiens 30-32 26742006-3 2016 PURPOSE: To investigate the tamoxifen predictive relevance of the AR protein expression in breast cancer. Tamoxifen 28-37 androgen receptor Homo sapiens 66-68 26742006-7 2016 RESULTS: In patients with oestrogen receptor (ER)-negative tumours, expression of AR predicted decreased recurrence rate with tamoxifen (hazard ratio (HR)=0.34; 95% confidence interval (CI)=0.14-0.81; P=0.015), whereas the opposite was seen in the AR- group (HR=2.92; 95% CI=1.16-7.31; P=0.022). Tamoxifen 126-135 androgen receptor Homo sapiens 82-84 26742006-9 2016 Patients with triple-negative and AR+ tumours benefitted from tamoxifen treatment (HR=0.12; 95% CI=0.014-0.95 P=0.044), whereas patients with AR- tumours had worse outcome when treated with tamoxifen (HR=3.98; 95% CI=1.32-12.03; P=0.014). Tamoxifen 62-71 androgen receptor Homo sapiens 34-36 26742006-12 2016 CONCLUSIONS: AR can predict tamoxifen treatment benefit in patients with ER- tumours and triple-negative breast cancer. Tamoxifen 28-37 androgen receptor Homo sapiens 13-15