Pub. Date : 2016 Jul
PMID : 26729049
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lacosamide inhibits calcitonin gene-related peptide production and release at trigeminal level in the rat. | Lacosamide | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | RESULTS: We found that: (1) lacosamide inhibits CGRP release from brainstem explants under basal conditions as well as after stimulation by 56 mM KCl, 10 muM veratridine or 1 muM capsaicin; and (2) the i.p. | Lacosamide | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | administration of nitroglycerine produces an increase in CGRP levels in the brainstem and trigeminal ganglia, which is inhibited by a pre-treatment with lacosamide. | Lacosamide | calcitonin-related polypeptide alpha | Rattus norvegicus |