Title : Proteasome inhibitor MG-132 enhances histone deacetylase inhibitor SAHA-induced cell death of chronic myeloid leukemia cells by an ROS-mediated mechanism and downregulation of the Bcr-Abl fusion protein.

Pub. Date : 2015 Nov

PMID : 26722260






2 Functional Relationships(s)
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1 Notably, the ROS scavenger, N-acetyl-L-cysteine, almost fully reversed the cell death and Bcr-Abl downregulation that was induced by the combination of SAHA and MG-132. Reactive Oxygen Species ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 These results indicated that increased intracellular ROS levels are important in the induction of cell death and the downregulation of Bcr-Abl. Reactive Oxygen Species ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens