Title : Reciprocal negative feedback loop between EZH2 and miR-101-1 contributes to miR-101 deregulation in hepatocellular carcinoma.

Pub. Date : 2016 Feb

PMID : 26718325






7 Functional Relationships(s)
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1 Reciprocal negative feedback loop between EZH2 and miR-101-1 contributes to miR-101 deregulation in hepatocellular carcinoma. mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
2 In the present study, we demonstrated that the miR-101 precursor pre-miR-101-1 could be regulated by an important epigenetic regulator, the enhancer of zeste homolog 2 (EZH2). mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
3 In the present study, we demonstrated that the miR-101 precursor pre-miR-101-1 could be regulated by an important epigenetic regulator, the enhancer of zeste homolog 2 (EZH2). mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
4 This mature miR-101-induced pre-miR-101 expression was specific to pre-miR-101-1 and depended on EZH2 activities. mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
5 This mature miR-101-induced pre-miR-101 expression was specific to pre-miR-101-1 and depended on EZH2 activities. mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
6 These findings show that elevated EZH2 contributes to miR-101 deregulation in HCC and highlight the coordinated role of miR-101 and EZH2 in hepatocarcinogenesis. mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
7 These findings show that elevated EZH2 contributes to miR-101 deregulation in HCC and highlight the coordinated role of miR-101 and EZH2 in hepatocarcinogenesis. mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens