Title : α-Synuclein dimerization in erythrocytes of Gaucher disease patients: correlation with lipid abnormalities and oxidative stress.

Pub. Date : 2016 Feb 2

PMID : 26708635






5 Functional Relationships(s)
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1 Correlation studies showed that in GD the alpha-Syn dimer/monomer ratio is positively correlated with the levels of glucosylceramide (GlcCer) and the glucosylceramide/ceramide (GlcCer/Cer) ratio and negatively with the levels of malonyldialdehyde (MDA) and plasmalogens. Glucosylceramides synuclein alpha Homo sapiens
2 Correlation studies showed that in GD the alpha-Syn dimer/monomer ratio is positively correlated with the levels of glucosylceramide (GlcCer) and the glucosylceramide/ceramide (GlcCer/Cer) ratio and negatively with the levels of malonyldialdehyde (MDA) and plasmalogens. Glucosylceramides synuclein alpha Homo sapiens
3 Correlation studies showed that in GD the alpha-Syn dimer/monomer ratio is positively correlated with the levels of glucosylceramide (GlcCer) and the glucosylceramide/ceramide (GlcCer/Cer) ratio and negatively with the levels of malonyldialdehyde (MDA) and plasmalogens. Glucosylceramides synuclein alpha Homo sapiens
4 Correlation studies showed that in GD the alpha-Syn dimer/monomer ratio is positively correlated with the levels of glucosylceramide (GlcCer) and the glucosylceramide/ceramide (GlcCer/Cer) ratio and negatively with the levels of malonyldialdehyde (MDA) and plasmalogens. Glucosylceramides synuclein alpha Homo sapiens
5 In conclusion, we have shown that the increased tendency of alpha-Syn to form dimers in the RBC membrane of patients with GD, is correlated with both the level of lipids, including GlcCer, the primary lipid abnormality in GD, and the increased oxidative stress observed in this disorder. Glucosylceramides synuclein alpha Homo sapiens