Title : Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice.

Pub. Date : 2016 Jan 26

PMID : 26708632






5 Functional Relationships(s)
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1 Thapsigargin (TG), an ER stressor, significantly increased the mRNA expression of immunoglobulin heavy chain binding protein (BiP), spliced X-box binding protein 1 (XBP1), activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP), and ERAD components, in hypothalamic cultures of WT mice with the same threshold (0.1muM) and similar time courses. Thapsigargin heat shock protein 5 Mus musculus
2 Thapsigargin (TG), an ER stressor, significantly increased the mRNA expression of immunoglobulin heavy chain binding protein (BiP), spliced X-box binding protein 1 (XBP1), activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP), and ERAD components, in hypothalamic cultures of WT mice with the same threshold (0.1muM) and similar time courses. Thapsigargin heat shock protein 5 Mus musculus
3 Thapsigargin (TG), an ER stressor, significantly increased the mRNA expression of immunoglobulin heavy chain binding protein (BiP), spliced X-box binding protein 1 (XBP1), activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP), and ERAD components, in hypothalamic cultures of WT mice with the same threshold (0.1muM) and similar time courses. Thapsigargin heat shock protein 5 Mus musculus
4 Thapsigargin (TG), an ER stressor, significantly increased the mRNA expression of immunoglobulin heavy chain binding protein (BiP), spliced X-box binding protein 1 (XBP1), activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP), and ERAD components, in hypothalamic cultures of WT mice with the same threshold (0.1muM) and similar time courses. Thapsigargin heat shock protein 5 Mus musculus
5 On the other hand, TG-induced upregulation of BiP and CHOP as well as most ERAD-related genes, but not spliced XBP1 or ATF4, was attenuated in ATF6alpha(-/-) mice compared with WT mice. Thapsigargin heat shock protein 5 Mus musculus