Title : Diagnosis, Management, and New Therapeutic Options in Childhood Neurofibromatosis Type 2 and Related Forms.

Pub. Date : 2015 Dec

PMID : 26706012






1 Functional Relationships(s)
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1 Data driven from in vitro and animal studies on the merlin pathway allowed biologically targeted treatment strategies (employing Lapatinib, Erlotinib, Everolimus, Picropodophyllin, OSU.03012, Imatinib, Sorafenib, and Bevacizumab) aimed at multiple tumor shrinkage or regression or both and tumor arrest of progression with functional improvement. Sorafenib NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens