Protein Name NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
Organism Homo sapiens
Gene ID 4771
Gene Symbol

NF2

UniProt P35240 (MERL_HUMAN), A0A024R1D9 (A0A024R1D9_HUMAN), A0A024R1J8 (A0A024R1J8_HUMAN), A0A024R1F6 (A0A024R1F6_HUMAN), A0A024R1J9 (A0A024R1J9_HUMAN), A0A024R1I0 (A0A024R1I0_HUMAN)
Relationships Total Number of functionally related compound(s) : 212
Total Number of Articles : 248
Description

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

Gene Summary

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022]

synonyms
  • merlin
  • bilateral acoustic neurofibromatosis
  • moesin-ezrin-radixin like
Click to show/hide the synonyms
Properties