Title : TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ.

Pub. Date : 2016 Jan 5

PMID : 26699475






1 Functional Relationships(s)
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1 We show that chronic activation with either bacterial lipopolysaccharide through Toll-like receptor 4 (TLR4) or leukocyte cytokine IFN-gamma induces reactive phenotypes in microglia associated with morphological changes, population expansion, CD11b and CD68 up-regulation, and proinflammatory cytokine (IL-1beta, TNF-alpha, IL-6) and nitric oxide (NO) release. Nitric Oxide interferon gamma Homo sapiens