Title : Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase.

Pub. Date : 2016 Jan 27

PMID : 26698536






1 Functional Relationships(s)
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1 A structure-activity relationship (SAR) study of these substances led to identification of pyridazinone 19 as a highly selective and potent c-Met tyrosine inhibitor, which displays favorable pharmacokinetic properties in mice and significant antitumor activity against a c-Met driven EBC-1 tumor xenograft. Tyrosine met proto-oncogene Mus musculus