Title : Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer.

Pub. Date : 2015 Dec

PMID : 26698249






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer. Cisplatin cyclin dependent kinase 5 Homo sapiens
2 The further mechanism investigated showed that cyclin I upregulated the expression of cyclin-dependent kinase 5 (Cdk5) promoting cisplatin resistance by preventing apoptosis in CC cell line. Cisplatin cyclin dependent kinase 5 Homo sapiens
3 The further mechanism investigated showed that cyclin I upregulated the expression of cyclin-dependent kinase 5 (Cdk5) promoting cisplatin resistance by preventing apoptosis in CC cell line. Cisplatin cyclin dependent kinase 5 Homo sapiens
4 Consistently, the cyclin I overexpressed Hela cell lines produce increased sensitivity to cisplatin treatment through knockdown of Cdk5 protein with siRNA. Cisplatin cyclin dependent kinase 5 Homo sapiens
5 CONCLUSIONS: These data suggest that a cyclin I-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer. Cisplatin cyclin dependent kinase 5 Homo sapiens