Pub. Date : 2015 Dec
PMID : 26698249
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer. | Cisplatin | cyclin dependent kinase 5 | Homo sapiens |
2 | The further mechanism investigated showed that cyclin I upregulated the expression of cyclin-dependent kinase 5 (Cdk5) promoting cisplatin resistance by preventing apoptosis in CC cell line. | Cisplatin | cyclin dependent kinase 5 | Homo sapiens |
3 | The further mechanism investigated showed that cyclin I upregulated the expression of cyclin-dependent kinase 5 (Cdk5) promoting cisplatin resistance by preventing apoptosis in CC cell line. | Cisplatin | cyclin dependent kinase 5 | Homo sapiens |
4 | Consistently, the cyclin I overexpressed Hela cell lines produce increased sensitivity to cisplatin treatment through knockdown of Cdk5 protein with siRNA. | Cisplatin | cyclin dependent kinase 5 | Homo sapiens |
5 | CONCLUSIONS: These data suggest that a cyclin I-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer. | Cisplatin | cyclin dependent kinase 5 | Homo sapiens |