Title : Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays.

Pub. Date : 2016 Feb 1

PMID : 26696140






1 Functional Relationships(s)
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1 We identified 2",7"-dichlorofluorescein (DCF), 4",5"-dibromofluorescein (DBF), and Oregon green (OG) as good OATP1B1 substrates with Km values of 5.29, 4.16, and 54.1 muM and Vmax values of 87.9, 48.1, and 187 pmol/min/mg protein, respectively. octyl-beta-D-glucoside solute carrier organic anion transporter family member 1B1 Homo sapiens