Title : IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer.

Pub. Date : 2015

PMID : 26693062






1 Functional Relationships(s)
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1 Additionally, the novel IKKbeta inhibitor CmpdA has been shown to consistently block the phosphorylation of NF-kappaB at serine 536 while also dramatically improving the efficacy of cisplatin in inhibition of cell proliferation and induction of apoptosis in the cisplatin resistant cancer cells. CMPDA nuclear factor kappa B subunit 1 Homo sapiens