Pub. Date : 2015 Dec 29
PMID : 26689986
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells. | Cisplatin | dual specificity phosphatase 1 | Mus musculus |
| 2 | Interestingly, at the molecular level, we present evidences showing how the phosphatase MKP1 is a major determinant of cisplatin sensitivity and its upregulation is strictly required for the induction of chemosensitivity mediated by E1a. | Cisplatin | dual specificity phosphatase 1 | Mus musculus |
| 3 | However, in resistant cell as H1299, H23 or H661, which display low levels of MKP1, E1a expression promotes a dramatic increase in the amount of MKP1 correlating with cisplatin sensitivity. | Cisplatin | dual specificity phosphatase 1 | Mus musculus |
| 4 | In summary, the present work reinforce the critical role of MKP1 in the cellular response to cisplatin highlighting the importance of this phosphatase in future gene therapy approach based on E1a gene. | Cisplatin | dual specificity phosphatase 1 | Mus musculus |