Protein Name dual specificity phosphatase 1
Organism Mus musculus
Gene ID 19252
Gene Symbol

Dusp1

UniProt P28563 (DUS1_MOUSE), Q3U8K3 (Q3U8K3_MOUSE)
Relationships Total Number of functionally related compound(s) : 153
Total Number of Articles : 160
Description

dual specificity phosphatase 1

Gene Summary

Enables mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of MAPK cascade; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • dual specificity protein phosphatase 1
  • MAP kinase phosphatase 1
  • mitogen-activated protein kinase phosphatase-1
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Properties