Pub. Date : 2016 Jan 15
PMID : 26688571
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | alpha-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1alpha and STAT3 signaling pathways. | alpha-solanine | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | alpha-solanine also suppressed the activation of phospho-ERK1/2 (p-ERK1/2), HIF-1alpha, and STAT3 signaling. | alpha-solanine | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | The results provide new evidence that alpha-solanine has a strong anti-cancer effect via the ERK1/2-HIF-1alpha and STAT3 signaling pathways and suggest that it may be a potential new drug. | alpha-solanine | hypoxia inducible factor 1 subunit alpha | Homo sapiens |