Pub. Date : 2016 Feb 28
PMID : 26683770
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that DPT induced glioma cell death in vitro and inhibited the growth of xenograft glioma in vivo, which was accompanied with parthanatos-related biochemical events including expressional upregulation of PARP-1, cytoplasmic accumulation of PAR polymer, and nuclear translocation of AIF. | deoxypodophyllotoxin | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | In vitro study revealed that genetic knockdown of PARP-1 with small interfering RNA attenuated DPT-induced elevation in the cytoplasmic PAR-polymer and the nuclear AIF, as well as protected glioma cells against the toxicity of DPT. | deoxypodophyllotoxin | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | In vitro study revealed that genetic knockdown of PARP-1 with small interfering RNA attenuated DPT-induced elevation in the cytoplasmic PAR-polymer and the nuclear AIF, as well as protected glioma cells against the toxicity of DPT. | deoxypodophyllotoxin | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 4 | Further, antioxidant NAC, as well as PARP-1 inhibitor 3AB, not only alleviated the overproduction of ROS caused by DPT, but also reversed the above-mentioned biochemical events, maintained mitochondrial membrane potential and rescued glioma cells death. | deoxypodophyllotoxin | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |