Pub. Date : 2016 Feb
PMID : 26683671
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus. | Hydrogen | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus. | Hydrogen | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | The subsequent in vitro experiments showed that H2 treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-kappaB and the expression of tumor necrosis factor alpha and interleukin-1beta, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus. | Hydrogen | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | In conclusion, H2 treatment can ameliorate the inflammatory response and reduce the expression of inflammatory mediators during the early phase of AP by inhibiting the MAPK pathways and increasing Hsc70 expression. | Hydrogen | mitogen-activated protein kinase 1 | Homo sapiens |