Pub. Date : 2016 Aug
PMID : 26678015
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of CYP3A Modulators on the Pharmacokinetics of Naloxegol. | naloxegol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | This study evaluated the effects of CYP3A inhibition and induction on the pharmacokinetics, safety, and tolerability of naloxegol. | naloxegol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Naloxegol was generally safe and well tolerated when given alone or coadministered with the respective CYP3A modulators; 1 subject discontinued because of elevations in liver enzymes attributed to rifampin. | naloxegol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The exposure of naloxegol was affected substantially by ketoconazole, diltiazem, and rifampin, suggesting that it is a sensitive in vivo substrate of CYP3A4. | naloxegol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |