Title : Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway.

Pub. Date : 2015 Dec 17

PMID : 26672975






2 Functional Relationships(s)
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1 Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway. Iron glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
2 We also demonstrate the operation of this phenomenon during inflammation, as an arm of the innate immune response where lactoferrin denies iron to invading microorganisms by chelating it and then itself being sequestered into surrounding host cells by GAPDH. Iron glyceraldehyde-3-phosphate dehydrogenase Homo sapiens