Pub. Date : 2016 Mar 3
PMID : 26670633
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VWF is dimerized in the endoplasmic reticulum by formation of disulfide bonds between the C-terminal cysteine knot (CK) domains of 2 monomers. | Disulfides | von Willebrand factor | Homo sapiens |
| 2 | On the basis of protein-protein docking and molecular dynamics simulations, combined with fluorescence microscopy studies of VWF CK-domain mutants, we suggest the following mechanism of VWF dimerization: PDI initiates VWF dimerization by forming the first 2 disulfide bonds Cys2771-2773" and Cys2771"-2773. | Disulfides | von Willebrand factor | Homo sapiens |
| 3 | On the basis of protein-protein docking and molecular dynamics simulations, combined with fluorescence microscopy studies of VWF CK-domain mutants, we suggest the following mechanism of VWF dimerization: PDI initiates VWF dimerization by forming the first 2 disulfide bonds Cys2771-2773" and Cys2771"-2773. | Disulfides | von Willebrand factor | Homo sapiens |