Title : Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.

Pub. Date : 2016 Feb

PMID : 26661043






1 Functional Relationships(s)
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1 Here, we investigate the pharmacology of the orthosteric binding site in GluD2 by examining the activity of analogs of D-Ser and GluN1 glycine site competitive antagonists at GluD2 receptors containing the lurcher mutation (GluD2(LC)), which promotes spontaneous channel activation. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens